Isana Glycerin Serum Dupes & Cheaper Alternatives
From 3 Reddit threads · Updated November 3, 2026
Glycerin-and-betaine moisture boost for dehydrated skin; limited Reddit feedback. Here's what Redditors reach for instead.
#1
Best Overall Alternative

Beta-Glucan Power Moisture Serum
iUNIK·Serum
See alternatives400,000ppm beta-glucan delivers serious damp-skin hydration
- Size: 50 ml
The why
A beta-glucan and glycerin humectant serum for dehydrated, tret-irritated skin, applied to damp skin before moisturizer. It layers neatly for many users, but acne-prone or rosacea-prone skin can face breakouts, heat, stinging, or redness.
One minus
Breakouts and closed comedones show up for some users
Good forDry Skin, Sensitive Skin
The original, at a glance
- Why people love it
- Glycerin serum for extra moisture
Other alternatives worth a look

Multi-form hyaluronic acid for water-light hydration · 151 recs
Combination SkinOily Skin
15% pure L-ascorbic acid; strongest vitamin C form · 53 recs
Under MakeupBrightening

Centella-focused seven-ingredient formula · 266 recs
Dry SkinCombination Skin
20% L-ascorbic acid with Ferulic Acid and Alpha Tocopherol · 188 recs
Oily SkinDewy Finish
15% L-ascorbic acid with tocopherol and ferulic acid · 67 recs
Dry SkinDewy Finish
Broad peptide blend for long-game anti-aging · 52 recs
GentleFine Lines & Wrinkles
Lightweight humectant layer for damp skin · 117 recs
Combination SkinSkin Barrier
Browse more
Reddit's best serums by ingredient list
Looking for a different product?