25% Vitamin C + Glutathione Clinical Serum — Reddit Reviews
Updated October 28, 2026
25% vitamin C serum brightens uneven tone; expensive, tiny bottle for some.
What the community says
A concentrated vitamin C serum combining tetrahexyldecyl ascorbate, ascorbyl glucoside, ascorbic acid, and glutathione for stubborn discoloration and glow. It suits experienced brightening routines, yet sensitive skin may react and the smallest size feels especially poor value.
What this means for you
What people love
- Vitamin C blend visibly fades discoloration and boosts glow
- Derivative-heavy formula keeps sensitive-skin users coming back
- Easy morning layering before sunscreen
Watch out for
- Smallest size feels like a $20 sample
- Full size costs $62 per ounce
- Ascorbic acid can still rule it out for reactive users
Product details
Skin Type
Product Traits
Key Ingredients
Skin type data limited
Where to buy
What the science says
Hyperpigmentation
Some evidence
Vitamin C: 9 studies tested it directly. See all 19 studies
What the studies found
- Most studies found vitamin C helped fade dark patches, especially melasma
- It often worked better than a placebo when put on the skin for melasma
- Used with microneedling or peels, it often improved dark patches more
- Some studies found it worked about as well as other dark-spot treatments, not better
- The side effects were usually mild and brief
Anti-Aging
Some evidence
Vitamin C: 4 studies tested it directly. See all 12 studies
What the studies found
- All 4 studies that tested it directly found it helped with signs of aging
- It improved the look and texture of sun-damaged skin more than a placebo
- It helped smooth wrinkles, roughness, crow’s-feet, and uneven skin tone
- It did not clearly beat a placebo for how much water the skin held
- No irritation or sensitivity was reported in one study
Research context, not treatment advice. Studies are about the ingredient, not necessarily this exact product.
Real Reddit threads — 14 mentions across 8 threads
Paula's Choice 25% Vitamin C + Glutathione Clinical Serum on Reddit, in one place — 8 threads from r/tretinoin, r/30PlusSkinCare and 2 more, summarized.
“Vitamin C w Paula’s choice 25% vitamin c + glutathione clinical serum”
Positive
“AM”
Positive
“Currently my routine is”
Positive
“Paula's Choice - $62 / 1 oz - "25% Vitamin C & glutathione clinical serum" - 23% THDA”
Mentioned
“I don’t believe Paula’s Choice is 25% THD since it has two types of vitamin C - THD and ascorbyl glucoside”
Mentioned
“In the FAQ’s it says 23% thd and 2% the other one”
Mentioned
“For sun damage, you can start by adding a vitamin C serum in the morning.”
Positive
“I like Paula's Choice 25% vitamin C with Glutathione”
Positive
“Paula's Choice 25% vitamin C with Glutathione or InnBeauty Project's Pro C Serum”
Positive
“3. Vitamin C - Paula’s Choice 25% Vitamin C + Glutathione Clinical Serum”
Positive
“Morning skincare routine:”
Positive
“I would like to incorporate a copper peptide serum into my evening skincare routine for anti-aging.”
Positive
“Paula’s Choice 25% Vitamin C + Glutathione Clinical Serum”
Cautionary
“I ordered the smallest size but in no way was I expecting a sample size for 20$!”
Cautionary
“I’ll not be repurchasing from this brand.”
Cautionary
“Other options:”
Mentioned
“Paula’s Choice 25% Vitamin C + Glutathione Clinical Serum”
Mentioned
