25% Vitamin C + Glutathione Clinical Serum — Reddit Reviews
Updated October 8, 2026
25% vitamin C serum that tackles glow and hyperpigmentation; can sting.
What the community says
A high-strength vitamin C serum built around tetrahexyldecyl ascorbate and ascorbyl glucoside, with glutathione in the mix. People chasing glow or PIH reach for it; very sensitive skin can hate the ascorbic acid side.
What this means for you
Backed by 5 threads from r/30PlusSkinCare, r/SkincareAddiction and 1 more.
Read the threads ↓What people love
- 25% vitamin C punch for glow and PIH
- Derivative-heavy formula with glutathione
- Liked by some who quit pricier vitamin C serums
Watch out for
- Ascorbic acid can sting sensitive skin
- Tiny size for the money
Product details
Skin Type
Key Ingredients
Skin type data limited
Where to buy
What the science says
Hyperpigmentation
Some evidence
Vitamin C: 7 studies tested it on its own. See all 24 studies
What the studies found
- Most studies found vitamin C helped fade dark patches or spots
- Studies in melasma found vitamin C on the skin made patches look lighter over time
- Used with other treatments, vitamin C often faded dark patches more than the other treatment alone
- Vitamin C worked about as well as glycolic acid for fading dark patches in melasma
- One study in sun spots found only weak fading, with mixed results across different skin-darkness scores
Research context, not treatment advice. Studies are about the ingredient, not necessarily this exact product.
Real Reddit threads — 11 mentions across 5 threads
Paula's Choice 25% Vitamin C + Glutathione Clinical Serum on Reddit, in one place — 5 threads from r/30PlusSkinCare, r/SkincareAddiction and 1 more, summarized.
“3. Vitamin C - Paula’s Choice 25% Vitamin C + Glutathione Clinical Serum”
Positive
“Morning skincare routine:”
Positive
“I would like to incorporate a copper peptide serum into my evening skincare routine for anti-aging.”
Positive
“Paula’s Choice 25% Vitamin C + Glutathione Clinical Serum”
Cautionary
“I ordered the smallest size but in no way was I expecting a sample size for 20$!”
Cautionary
“I’ll not be repurchasing from this brand.”
Cautionary
“Other options:”
Mentioned
“Paula’s Choice 25% Vitamin C + Glutathione Clinical Serum”
Mentioned
“Paula’s Choice 25% Vitamin C + Glutathione Clinical Serum”
Mentioned
“AM protocol - Cleanser, AA and Vit C, serums, moisturizer and sunscreen”
Mentioned
“The below are the most impactful actives I used:”
Mentioned
“Paula's Choice 25% Vitamin C + Glutathione Clinical Serum”
Positive
“This got rid of the PIE and PIH in a few months”
Positive
“*Let soak in*”
Positive
