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Azelaic Acid 12% Serum

AcneSerum

Azelaic Acid 12% Serum — Reddit Reviews

by TIRTIR

91nextscore17 verdicts

Updated October 16, 2026

Studies support 12% azelaic acid for acne; Redditors report redness and barrier drama.

What the community says

Backed by 64 studies

A 12% azelaic acid serum with panthenol, zinc PCA, and barrier-supporting ceramide NP for acne-prone, redness-prone skin. Studies back azelaic acid for acne, while Redditors say this formula can sting, dry them out, or trigger breakouts.

From Reddit

Backed by 25 threads from r/tretinoin, r/Rosacea and 4 more.

Read the threads ↓

What people love

Watch out for

  • Can strip the barrier and dry out dehydrated skin
  • Burning, redness, and irritation reported with consistent use
  • Tacky, heavy texture reportedly triggers breakouts

Product details

Where to buy

What the science says vs. what Reddit says

  • Acne

    Strong evidence

    Azelaic Acid: 22 studies tested it on its own. See all 31 studies

    On Reddit: Pimples shrink and disappear without leaving scar pigmentation, according to one user's experience. 5 mentions

    What the studies found
    • Most studies found it helped clear acne
    • It cleared acne better than a placebo in several studies
    • It often worked about as well as tretinoin and some other common acne treatments
    • Some studies found it worked less well than benzoyl peroxide or benzoyl peroxide with clindamycin
    • Side effects were usually local and moderate, with fewer local side effects than tretinoin in one study

    Studied at 5–20%this product: 12%

  • Rosacea

    Strong evidence

    Azelaic Acid: 17 studies tested it on its own. See all 20 studies

    What the studies found
    • Most studies found it helped rosacea more than a placebo
    • It often reduced red bumps and redness
    • It worked about as well as metronidazole, and some studies found it worked better
    • Some studies found better overall skin ratings and quality of life
    • The most common side effects were mild stinging and other mild local skin reactions, with no serious treatment-related side effects reported

    Studied at 15–20%this product: 12%

  • Hyperpigmentation

    Strong evidence

    Azelaic Acid: 12 studies tested it on its own. See all 16 studies

    What the studies found
    • Most studies found azelaic acid helped fade dark patches better than a placebo
    • In melasma, it often made patches lighter and less widespread
    • It worked about as well as hydroquinone in some studies, and better than weaker hydroquinone in others
    • It also helped fade dark marks left after acne in one study
    • The most common side effects were burning and stinging, and severe side effects were not reported

    Studied at 15–20%this product: 12%

Research context, not treatment advice. Studies are about the ingredient, not necessarily this exact product.

Real Reddit threads — 34 mentions across 25 threads

TIRTIR Azelaic Acid 12% Serum on Reddit, in one place — 25 threads from r/tretinoin, r/Rosacea and 4 more, summarized.

“TIRTIR actually has an azelaic acid serum that I’m thinking of trying next.”

Mentioned

“I’m thinking of trying next”

Mentioned

“TIRTIR actually has an azelaic acid serum”

Mentioned

“I started using Tirtir’s 12% azelaic acid and my skin agreed with it so much more.”

Positive

“It contains panthenol and zinc”

Positive

“which I think helps me tolerate it as well as not aggrevate my barrier!”

Positive

“I have been using the tir tir one and havent noticed any irritation at all and it is 12%!”

Positive

“oh this was a way better purchase for me since i have perioral dermatitis and was treating an outbreak.”

Positive

“I love the tirtir azelaic acid serum. It has improved the texture and redness on my cheeks.”

Positive

“TirTir Azaelic Acid Serum 12% - 8/10 saw a difference in a week.”

Positive

“Made my skin so soft and smooth.”

Positive

“I've been eyeing tirtir azelaic acid serum for a while now. Does it do a good job with dark spots?”

Positive

“i saw faster results with the tirtir but had to stop using it because it was too stripping and broke my barrier.”

Positive

“it was drying me out and causing my skin to flare.”

Positive

“Repurchased the Tittir one. My skin is sensitive and dehydrated, prone to redness. I've seen some good results over the months and really helps with the redness.”

Positive

“Eta: i use the tirtir 12% azelaic acid serum.”

Positive

“I have noticed that it helps shrink my pimples and once gone, the pimples don’t leave any scar pigmentation.”

Positive

“Currently using the Dr.Althea Vit C Boosting Serum 63% and the TirTir Azelaic Acid 12% Serum”

Positive

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