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Azelaic Acid 12% Serum

AcneSerum

Azelaic Acid 12% Serum — Reddit Reviews

by TIRTIR

88nextscore19 verdicts

Updated October 21, 2026

Studies found azelaic acid clears acne; Redditors report calmer redness and fewer breakouts.

What the community says

Backed by 57 studies

The 12% azelaic acid serum pairs an acne-focused active with panthenol and Zinc PCA in a watery, layerable formula. Studies found azelaic acid helps acne, and Redditors report redness improvements; irritated, dehydrated skin may find it stripping.

From Reddit

Backed by 27 threads from r/tretinoin, r/Rosacea and 4 more.

Read the threads ↓

What people love

  • 12% azelaic acid; unusually strong for an over-the-counter serum
  • Redditors report fewer pimples and less post-breakout pigmentation
  • Watery, fast-absorbing texture that layers without pilling

Watch out for

Product details

Where to buy

What the science says vs. what Reddit says

  • Acne

    Strong evidence

    Azelaic Acid: 22 studies tested it on its own. See all 31 studies

    On Reddit: Shrinking pimples without scar pigmentation is one user's reported payoff. 5 mentions

    What the studies found
    • Most studies found it helped clear acne
    • It cleared acne better than a placebo in several studies
    • It often worked about as well as tretinoin and some other common acne treatments
    • Some studies found it worked less well than benzoyl peroxide or benzoyl peroxide with clindamycin
    • Side effects were usually local and moderate, with fewer local side effects than tretinoin in one study

    Studied at 5–20%this product: 12%

  • Rosacea

    Strong evidence

    Azelaic Acid: 15 studies tested it on its own. See all 17 studies

    What the studies found
    • Most studies found azelaic acid helped rosacea more than a placebo
    • It often reduced bumps and redness from rosacea
    • It worked about as well as metronidazole in some studies, and better in others
    • It did not seem to help visible blood vessels
    • Side effects were mainly mild to moderate, including stinging

    Studied at 15–20%this product: 12%

  • Hyperpigmentation

    Some evidence

    Azelaic Acid: 9 studies tested it on its own. See all 12 studies

    What the studies found
    • Most studies found it helped fade dark patches, especially melasma
    • It faded melasma better than a placebo in one clinical trial
    • It often worked about as well as hydroquinone, and some studies found it worked better
    • It may help dark marks left after acne, but one study found no clear benefit for sun spots
    • The most common side effects were irritation, burning and stinging

    Studied at 15–20%this product: 12%

Research context, not treatment advice. Studies are about the ingredient, not necessarily this exact product.

Real Reddit threads — 36 mentions across 27 threads

TIRTIR Azelaic Acid 12% Serum on Reddit, in one place — 27 threads from r/tretinoin, r/Rosacea and 4 more, summarized.

“TIRTIR actually has an azelaic acid serum that I’m thinking of trying next.”

Mentioned

“I’m thinking of trying next”

Mentioned

“TIRTIR actually has an azelaic acid serum”

Mentioned

“I started using Tirtir’s 12% azelaic acid and my skin agreed with it so much more.”

Positive

“It contains panthenol and zinc”

Positive

“which I think helps me tolerate it as well as not aggrevate my barrier!”

Positive

“I have been using the tir tir one and havent noticed any irritation at all and it is 12%!”

Positive

“oh this was a way better purchase for me since i have perioral dermatitis and was treating an outbreak.”

Positive

“I love the tirtir azelaic acid serum. It has improved the texture and redness on my cheeks.”

Positive

“TirTir Azaelic Acid Serum 12% - 8/10 saw a difference in a week.”

Positive

“Made my skin so soft and smooth.”

Positive

“I've been eyeing tirtir azelaic acid serum for a while now. Does it do a good job with dark spots?”

Positive

“i saw faster results with the tirtir but had to stop using it because it was too stripping and broke my barrier.”

Positive

“it was drying me out and causing my skin to flare.”

Positive

“Repurchased the Tittir one. My skin is sensitive and dehydrated, prone to redness. I've seen some good results over the months and really helps with the redness.”

Positive

“Eta: i use the tirtir 12% azelaic acid serum.”

Positive

“I have noticed that it helps shrink my pimples and once gone, the pimples don’t leave any scar pigmentation.”

Positive

“Currently using the Dr.Althea Vit C Boosting Serum 63% and the TirTir Azelaic Acid 12% Serum”

Positive

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