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Azelaic Advanced

Combination SkinAcne Spot Treatment

Azelaic Advanced — Reddit Reviews

by Regimen Lab

95nextscore24 verdicts

Updated October 13, 2026

Azelaic serum absorbs cleanly under makeup; tingles on dry skin.

What the community says

Backed by 64 studies

This azelaic serum has a light, non-greasy finish that absorbs cleanly and layers under makeup. Redditors use it alongside tretinoin, with less stinging when applying it to hydrated skin or completely dry skin.

From Reddit

Backed by 23 threads from r/koreanskincare, r/Rosacea and 3 more.

Read the threads ↓

What people love

  • Light serum that disappears under makeup
  • Absorption-focused solubilized 10% azelaic acid
  • Less burning than competing azelaic products

Watch out for

  • Stings when you rush application after cleansing
  • Can feel drying without extra hydration
  • Expensive for an OTC serum

Product details

Where to buy

What the science says

  • Acne

    Strong evidence

    Azelaic Acid: 22 studies tested it on its own. See all 31 studies

    What the studies found
    • Most studies found it helped clear acne
    • It cleared acne better than a placebo in several studies
    • It often worked about as well as tretinoin and some other common acne treatments
    • Some studies found it worked less well than benzoyl peroxide or benzoyl peroxide with clindamycin
    • Side effects were usually local and moderate, with fewer local side effects than tretinoin in one study

    Studied at 5–20%this product: 10%

  • Rosacea

    Strong evidence

    Azelaic Acid: 17 studies tested it on its own. See all 20 studies

    What the studies found
    • Most studies found it helped rosacea more than a placebo
    • It often reduced red bumps and redness
    • It worked about as well as metronidazole, and some studies found it worked better
    • Some studies found better overall skin ratings and quality of life

    Studied at 15–20%this product: 10%

  • Hyperpigmentation

    Strong evidence

    Azelaic Acid: 12 studies tested it on its own. See all 16 studies

    What the studies found
    • In melasma, it often made patches lighter and less widespread
    • It worked about as well as hydroquinone in some studies, and better than weaker hydroquinone in others
    • It also helped fade dark marks left after acne in one study
    • The most common side effects were burning and stinging, and severe side effects were not reported

    Studied at 15–20%this product: 10%

Research context, not treatment advice. Studies are about the ingredient, not necessarily this exact product.

Real Reddit threads — 29 mentions across 23 threads

Regimen Lab Azelaic Advanced on Reddit, in one place — 23 threads from r/koreanskincare, r/Rosacea and 3 more, summarized.

“* Regimen Lab Azelaic Advanced”

Positive

“Excuse me just listing the relevant products/techniques from my routine...”

Positive

“RELEVANT PRODUCTS FROM NIGHT...”

Positive

“I’m using Regimen and it doesn’t burn or anything”

Positive

“I love the regimen lab one! It blows all the other over-the-counter azelaics I've tried out of the water.”

Positive

“I do find the regimen lab tingles unless I put it on very hydrated skin though.”

Positive
56

“Not a cream, but the best OTC azelaic acid you can get is Regimen Lab Azelaic Advanced.”

Mentioned

“Came here looking for alternatives as well.”

Mentioned

“Anyone have any brand recs since I won't be able to purchase from dermatica anymore?”

Mentioned

“the Regimen Lab azelaic Advanced acid.”

Positive

“They’re fantastic.”

Positive

“Other than that I use Tretinoin and the Regimen Lab azelaic Advanced acid.”

Positive

“regimen lab 10/10”

Mentioned

“Regimen Labs”

Mentioned

“If you’re in Canada, the Regimen Labs one is excellent!”

Mentioned

“I just bought Remedy vitamin C and Regimen Lab azelaic acid, can’t wait to use them and have my PIE and PIH go awayyy”

Mentioned

“Give Azelaic acid a try. Anua has a good one.”

Mentioned

“What helped me most was daily sunscreen, azelaic acid”

Mentioned

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