Combination SkinAcne Spot Treatment
Azelaic Advanced — Reddit Reviews
by Regimen Lab
Updated September 23, 2026
10% azelaic acid with extra azelaic derivatives; Reddit calls it an OTC standout.
What the community says
A 10% azelaic acid serum stacked with azelaic derivatives and soothing extras. Redditors use it for redness-prone, combo, and rosacea-leaning skin that wants an OTC azelaic without a tacky film. It can sting or feel dry on less-hydrated skin.
What this means for you
What people love
- Absorbs fast, not tacky
- Plays nicely with tretinoin
- OTC azelaic acid standout
Watch out for
Product details
Where to buy
What the science says
Acne
Strong evidence
Azelaic Acid: 22 studies tested it on its own. See all 31 studies
What the studies found
- Most studies found azelaic acid helped clear acne
- It often reduced pimples, blackheads, whiteheads, and red, sore spots
- It usually worked about as well as tretinoin and some other common acne treatments
- Some studies found it worked less well than benzoyl peroxide
- The most common side effects were local skin irritation, peeling, dryness, and stinging
Studied at 5–20%this product: 10%
Hyperpigmentation
Strong evidence
Azelaic Acid: 12 studies tested it on its own. See all 15 studies
What the studies found
- Most studies found azelaic acid helped fade dark spots or patches
- It faded melasma patches better than a placebo in several studies
- It often worked about as well as hydroquinone, and sometimes better than weaker hydroquinone
- It also helped fade dark marks left after acne in one small study
- The most common side effects were mild burning, stinging, itching, redness and scaling
Studied at 15–20%this product: 10%
Research context, not treatment advice. Studies are about the ingredient, not necessarily this exact product.
Real Reddit threads — 23 mentions across 19 threads
Regimen Lab Azelaic Advanced on Reddit, in one place — 19 threads from r/koreanskincare, r/Rosacea and 3 more, summarized.
“* Regimen Lab Azelaic Advanced”
Positive
“Excuse me just listing the relevant products/techniques from my routine...”
Positive
“RELEVANT PRODUCTS FROM NIGHT...”
Positive
“I’m using Regimen and it doesn’t burn or anything”
Positive
“I love the regimen lab one! It blows all the other over-the-counter azelaics I've tried out of the water.”
Positive
“I do find the regimen lab tingles unless I put it on very hydrated skin though.”
Positive
“Not a cream, but the best OTC azelaic acid you can get is Regimen Lab Azelaic Advanced.”
Mentioned
“Came here looking for alternatives as well.”
Mentioned
“Anyone have any brand recs since I won't be able to purchase from dermatica anymore?”
Mentioned
“Many people recommend RegimenLab Azelaic Acid, which I'm planning to get once my skin gets better.”
Mentioned
“Are there any other OTC alternatives that you recommend?”
Mentioned
“what are we doing to get through this?”
Mentioned
“the Regimen Lab azelaic Advanced acid.”
Positive
“They’re fantastic.”
Positive
“Other than that I use Tretinoin and the Regimen Lab azelaic Advanced acid.”
Positive
“I just bought Remedy vitamin C and Regimen Lab azelaic acid, can’t wait to use them and have my PIE and PIH go awayyy”
Mentioned
“Give Azelaic acid a try. Anua has a good one.”
Mentioned
“What helped me most was daily sunscreen, azelaic acid”
Mentioned
