PDRN Hyaluronic Acid 100 Moisturizing Cream — Reddit Reviews
by Anua
Updated November 10, 2026
Sodium DNA and multi-weight hyaluronic acid hydrate dehydrated skin; breakouts remain real.
What the community says
A rich Sodium DNA, squalane, and multi-weight hyaluronic acid cream for dehydrated or barrier-stressed skin, especially after tretinoin. It layers well over serums, but oily, clog-prone users report closed comedones, cystic acne, and extra shine.
What this means for you
What people love
- Sodium DNA plus multiple hyaluronic acid forms
- Works under sunscreen and over serums
- Barrier-repairing support during tretinoin routines
Watch out for
- Breakouts and cystic acne reported, including in non-sensitive skin
- Closed comedones and tiny bumps are recurring complaints
- Feels thick and heavy; can increase shine
Product details
Use caution
Key Ingredients
What TikTok says
From 9 TikTok videos4 sponsored, marked with outlined numbers
Creators disagree on barrier repair: one pharmacist rates it 8/10 for barrier repair and says it suits dry or damaged skin 1, while another rates it 4/10 because it lacks lipid components 2. Sponsored creators say it gives a smooth base for makeup 34, and one unsponsored creator agrees 5. Creators warn it may feel too heavy for oily or acne-prone skin 1, while another finds it too lightweight for most seasons 6.
Sponsored means the creator disclosed a brand partnership or the video ran as a paid ad.
Videos open on TikTok in a new tab.
Where to buy
What the science says
Hyaluronic acid has some evidence for helping dehydrated skin 1. Both studies that tested it directly found it helped skin hold more water, and one found it helped more than a placebo 1. A single study also reported that skin felt firmer and some wrinkles looked less deep 1. The support rests on only three studies in total 1.
- Hyaluronic Acid for dehydration Some evidence · 3 studies
Research context, not treatment advice. Studies are about the ingredient, not necessarily this exact product.
How we grade researchFull ingredient list · 48
Anua PDRN Hyaluronic Acid 100 Moisturizing Cream ingredients
Water, Squalane, Glycerin, Hydrolyzed Collagen, 1,2-Hexanediol, Methylpropanediol, Ethylhexylglycerin, Niacinamide, Butylene Glycol, Sodium DNA, Pentylene Glycol, PVM/MA Copolymer, Carbomer, Diphenylsiloxy Phenyl Trimethicone, PCA Dimethicone, Behenyl Alcohol, Ammonium Acryloyldimethyltaurate/VP Copolymer, Propanediol, C14-22 Alcohols, C12-20 Alkyl Glucoside, Diglycerin, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, C12-13 Alketh-9, Melia Azadirachta Leaf Extract, Melia Azadirachta Flower Extract, Coccinia Indica Fruit Extract, Solanum Melongena (Eggplant) Fruit Extract, Aloe Barbadensis Flower Extract, Ocimum Sanctum Leaf Extract, Corallina Officinalis Extract, Curcuma Longa (Turmeric) Root Extract, Sodium Hyaluronate, Dimethylsilanol Hyaluronate, Hydrolyzed Hyaluronic Acid, Hydrolyzed Sodium Hyaluronate, Potassium Hyaluronate, Hyaluronic Acid, Hydroxypropyltrimonium Hyaluronate, Sodium Hyaluronate Crosspolymer, Sodium Hyaluronate Dimethylsilanol, Sodium Acetylated Hyaluronate, Adenosine, Sodium Phytate, Aminomethyl Propanediol, Madecassoside, Asiaticoside, Centella Asiatica Leaf Extract
Listed in label order, highest concentration first. Linked ingredients have their own page.
Real Reddit threads — 104 mentions across 27 threads
Anua PDRN Hyaluronic Acid 100 Moisturizing Cream on Reddit, in one place — 27 threads from r/tretinoin, r/koreanskincare and 4 more, summarized.
“On non taz nights, routine is the same except I layer on the Atobarrier OR anua PDRN hyaluronic acid moisturizing cream”
Positive
“Also here’s my full routine!! ❤️”
Positive
“I usually do 2 nights on, one night off.”
Positive
“I LOVE and will be definitely repurchasing the pdrn moisturizer, and I currently have on the pdrn and hyaluron mask”
Positive
“I really recommend them.”
Positive
“The Anua PDRN moisturiser is amazing.”
Positive
“I use Anua Hyaluronic acid 100 moisturizer.”
Positive
“PDRN literally changed my skin/hydration in less than three weeks.”
Positive
“I’d imagine other PDRN products would help with hydration as well.”
Positive
“I am using the anua PDRN hyaluronic acid”
Mentioned
“rn.”
Mentioned
“OOO explain more on anua and skin1004”
Mentioned
“i also tried the anua pdrn cream but it didnt really do anything for me”
Cautionary
“for combo skin the Anua pdrn one is good but note that topical pdrn is mostly just hydrating”
Positive
“i've tried 3/4 this is prob my ranking 1. anua pdrn SUPER HYDRATING rlly good if u are dehydrated combo”
Positive
“Not the 100 one. I got such a bad breakout a couple months ago and I’m still trying to fix it from that one”
Positive
Dupes & Alternatives
Often paired with
Products Redditors use alongside this one
iUNIK
Beta-Glucan Power Moisture Serum
Mentioned together in 8 threads
“iUNIK beta glucan serum with Purito oat in calming gel or Anua pdrn cream.”