TNS Advanced+ Serum — Reddit Reviews
by SkinMedica
Updated October 29, 2026
Peptide and conditioned-media serum with visible anti-aging results; financially unsustainable.
What the community says
A peptide and human fibroblast conditioned media serum aimed at fine lines, texture, and post-treatment recovery. It suits mature or dry, sensitive skin, yet luxury pricing and occasional irritation make patch testing and realistic expectations non-negotiable.
What this means for you
Backed by 17 threads from r/30PlusSkinCare, r/scacjdiscussion and 5 more.
Read the threads ↓What people love
Product details
Concerns
Skin Type
Product Traits
Key Ingredients
Where to buy
What the science says vs. what Reddit says
Anti-Aging
Not proven yet
Few or mixed studies. This claim isn't established.
Peptides: 2 studies tested it directly. See all 6 studies
On Reddit: Around the eyes, one 44-year-old user reports seeing her most noticeable results. 6 mentions
What the studies found
- Both studies that tested it directly found it helped with signs of aging
- It improved skin firmness in both studies
- Some signs of aging improved, including wrinkles, skin texture, hydration, and facial shape
- Wrinkle changes were small in one study, so results may differ by aging sign
- No reported side effects included stinging or itching
Research context, not treatment advice. Studies are about the ingredient, not necessarily this exact product.
Real Reddit threads — 45 mentions across 17 threads
SkinMedica TNS Advanced+ Serum on Reddit, in one place — 17 threads from r/30PlusSkinCare, r/scacjdiscussion and 5 more, summarized.
“Skinmedica TNS has strong research.”
Mentioned
“For topicals, I’d go for research- based peptides”
Mentioned
“These may soften the look of your marionette lines a bit”
Mentioned
“TNS Advanced 😭”
Positive
“TNS Advanced+ Serum”
Positive
“TNS”
Positive
“SkinMedica TNS Advanced+ Serum in combo with lasers, microneedling, and Sculptra”
Positive
“TNS Advanced+ Serum in combo with lasers, microneedling, and Sculptra”
Positive
“SkinMedica TNS Advanced+ Serum”
Positive
“Epidermal growth factors. I almost never hear anyone on the skincare subs talk about it, but it's made my skin look 10x better than tretinoin ever did.”
Positive
“within a couple weeks my skin was radiant.... like I hadn't seen since childhood.”
Positive
“THIS. The skinmedica TNS serum is soooooo good!”
Positive
“I use SkinMedica TNS Advanced+ Serum, HA5 Hydra Collagen, SPF 30 sunscreen daily, and topical eye patches.”
Mentioned
“For context, I take pretty good care of my skin and overall health.”
Mentioned
“I use SkinMedica TNS Advanced+ Serum...”
Mentioned
“And some peptides and growth factors do work!”
Positive
“I borrowed my mom's skinmedica TNS after a treatment and wow it did calm down my skin immediately.”
Positive
“That said, there are certain ingredients that can make a genuinely noticeable difference.”
Positive
