TNS Advanced+ Serum — Reddit Reviews
by SkinMedica
Updated September 24, 2026
Growth-factor serum with real anti-aging cred; pricey but people see it.
What the community says
A peptide-and-growth-factor serum people use for fine lines, laxity, and under-eye improvement. It layers before tretinoin or moisturizer, and some users keep it in rotation twice daily. The sting is the $300-ish price and occasional irritation.
What this means for you
Backed by 18 threads from r/30PlusSkinCare, r/scacjdiscussion and 6 more.
Read the threads ↓What people love
Watch out for
Product details
Where to buy
Real Reddit threads — 33 mentions across 18 threads
SkinMedica TNS Advanced+ Serum on Reddit, in one place — 18 threads from r/30PlusSkinCare, r/scacjdiscussion and 6 more, summarized.
“Skinmedica TNS has strong research.”
Mentioned
“For topicals, I’d go for research- based peptides (copper tripeptide-1, matrixyl family peptides) and growth factors over PDRN.”
Mentioned
“These may soften the look of your marionette lines a bit but procedures or injections will have the biggest effect.”
Mentioned
“SkinMedica TNS Advanced+ Serum in combo with lasers, microneedling, and Sculptra”
Positive
“TNS Advanced+ Serum in combo with lasers, microneedling, and Sculptra”
Positive
“SkinMedica TNS Advanced+ Serum”
Positive
“Epidermal growth factors. I almost never hear anyone on the skincare subs talk about it, but it's made my skin look 10x better than tretinoin ever did.”
Positive
“within a couple weeks my skin was radiant.... like I hadn't seen since childhood.”
Positive
“THIS. The skinmedica TNS serum is soooooo good!”
Positive
“I use SkinMedica TNS Advanced+ Serum, HA5 Hydra Collagen, SPF 30 sunscreen daily, and topical eye patches.”
Mentioned
“For context, I take pretty good care of my skin and overall health.”
Mentioned
“I use SkinMedica TNS Advanced+ Serum...”
Mentioned
“I borrowed my mom's skinmedica TNS after a treatment”
Positive
“wow it did calm down my skin immediately.”
Positive
“And some peptides and growth factors do work!”
Positive
“the TNS line.”
Positive
“products like their TNS serum are always in my rotation no matter what.”
Positive
“SkinMedica does not miss”
Positive
