Best Treatments for Cystic Acne

Ranked by community score across 24 mentions on Reddit

Top picks· 5

Reddit’s top pick

Differin10 mentions

The why

Studies found adapalene clears acne about as well as salicylic acid and benzoyl peroxide. Redditors treat it like the OTC retinoid starter pack for clogged pores and hormonal breakouts, but the purge, dryness, and eye irritation are very real.

One minus

Purge can last 6-12 weeks

Good forOily Skin, Combination Skin

Sulfur Ointment
10% sulfur treatment clears breakouts fast; can dry and sting.
De La Cruz5 mentions
Where to buy
Pair Acne Cream W
Ibuprofen piconol spot cream for angry pimples; shrinks, flattens, and calms redness.
Lion3 mentions
Azelaic Acid Suspension 10%
Azelaic acid 10% for redness, acne, and dark marks; pills hard.
The Ordinary3 mentions
Skin Perfecting 2% BHA Liquid Exfoliant
Salicylic acid BHA clears clogged pores; studies back acne benefits.
Paula's Choice3 mentions

Community take

For cystic acne, Redditors most often reach for adapalene gel (Differin) for its affordability and effectiveness. Other notable treatments include sulfur ointment and azelaic acid. These topical options help clear persistent cystic breakouts when used consistently.

What works

Adapalene gel is an effective and affordable OTC option for cystic acne.
Sulfur ointment and azelaic acid offer alternative treatment choices.
Works well as a spot treatment and for overall persistent acne control.

Watch out for

Adapalene can cause irritation if overused or applied in large amounts.
Requires gradual introduction starting every other night to avoid sensitivity.
Some users experience initial worsening or dryness before improvement.

Best Treatments for Cystic Acne

Top picks· 5

Community take

What works

Watch out for

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