E45 Dermatological Cream Dupes & Cheaper Alternatives

From 8 Reddit threads · Updated October 13, 2026

76nextscore· 5 verdicts

Paraffin-rich barrier cream for eczema flares; mixed results on irritated faces. The catch: can sting freshly irritated skin. Here's what Redditors reach for instead.

#1

Best Overall Alternative

2,074mentions

Cicaplast Balm B5+

La Roche-Posay·Moisturizer

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Barrier-repair staple for tret nights

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Size: 40 ml

The why

A thick barrier balm built around panthenol, centella asiatica leaf extract, madecassoside, and dimethicone. It suits dehydrated, red, over-exfoliated skin and the tret crowd. Oily or clog-prone faces often hate it; YMMV.

One minus

Very heavy; can clog oily or acne-prone skin

Good forDry Skin, Sensitive Skin

The original, at a glance

E45 Dermatological Cream

Why people love it: Basic barrier moisturizer for dry-skin routines

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