← Best Benzoyl Peroxide products
Peer-reviewed research on Benzoyl Peroxide, summarised in plain language. Every study links to its record on PubMed so you can read it yourself.
Comparative efficacy of clindamycin phosphate with benzoyl peroxide versus clindamycin phosphate with adapalene in acne vulgaris: a systematic review and meta-analysis.
Scientific reports2025Meta-analysis800 participants3%Positive
In a review of 800 people with acne, benzoyl peroxide with clindamycin cleared acne about as well as adapalene with clindamycin and caused fewer side effects.
Efficacy of topical treatments for mild-to-moderate acne: A systematic review and meta-analysis of randomized control trials.
Journal of the European Academy of Dermatology and Venereology : JEADV2025Meta-analysis33,472 participantsPositive
In a large review of 33472 people with mild-to-moderate acne, benzoyl peroxide used on its own cleared acne better than a placebo.
Treatments for Moderate-to-Severe Acne Vulgaris: A Systematic Review and Network Meta-analysis.
Journal of drugs in dermatology : JDD2024Meta-analysis3.1%Positive
In a large review of studies in people with moderate-to-severe acne, a 3-ingredient gel with benzoyl peroxide ranked among the most effective treatments.
Acne and the cutaneous microbiome: A systematic review of mechanisms and implications for treatments.
Journal of the European Academy of Dermatology and Venereology : JEADV2025Systematic reviewPositive
A large review of acne studies found benzoyl peroxide changed skin microbe diversity and was linked to acne clearing.
Guidelines of care for the management of acne vulgaris.
Journal of the American Academy of Dermatology2024Systematic reviewPositive
Expert guidelines recommend benzoyl peroxide for acne based on a review of the available evidence.
Topical, light-based, and complementary interventions for acne: an overview of systematic reviews.
The Cochrane database of systematic reviews2024Systematic review1,012 participantsMixed
In a large review of acne trials, benzoyl peroxide may help clear pimples, blackheads and whiteheads over 12 weeks, but the evidence was very uncertain and side effects may be more common.
Clindamycin Phosphate 1.2%/Adapalene 0.15%/Benzoyl Peroxide 3.1% Gel for Acne: Pooled Analysis by Age and Sex.
Journal of drugs in dermatology : JDD2026RCT657 participants3.1%Positive
In 3 clinical trials lasting 12 weeks, a gel with benzoyl peroxide used with other ingredients cleared acne better than a placebo.
Efficacy and safety of fixed-dose clindamycin phosphate 1.2%/adapalene 0.15%/benzoyl peroxide 3.1% gel in Hispanic participants with moderate-to-severe acne: a pooled analysis.
The Journal of dermatological treatment2025RCT147 participants3.1%Positive
In a 12-week study of 147 Hispanic or Latino people with acne, a gel with benzoyl peroxide cleared acne better than a placebo.
Clindamycin Phosphate 1.2%/Adapalene 0.15%/ Benzoyl Peroxide 3.1% Gel for Moderate-to-Severe Acne: A Pooled Analysis by Age.
Journal of drugs in dermatology : JDD2025RCT657 participants3.1%Positive
In 657 people with moderate-to-severe acne, a 12-week gel with benzoyl peroxide helped clear acne more than a placebo.
Efficacy and Tolerability of a Novel Cosmetic and Over-the-Counter Facial Acne Regimen Versus a Prescription Treatment.
Journal of cosmetic dermatology2025RCT54 participants2.5%Positive
In a 12-week study of 54 adults with acne, a regimen with benzoyl peroxide cleared acne about as well as the comparison regimen.
Efficacy of a multitargeted, salicylic acid-based dermocosmetic cream compared to benzoyl peroxide 5% in Acne vulgaris: Results from a randomized study.
Journal of cosmetic dermatology2024RCT150 participants5%Positive
In a 56-day study of 150 people with mild to moderate acne, benzoyl peroxide 5% improved acne about as well as the other cream tested.
Early and Sustained Acne Lesion Reductions With Fixed-Dose Clindamycin Phosphate 1.2%/Adapalene 0.15%/Benzoyl Peroxide 3.1% Gel.
Journal of drugs in dermatology : JDD2024RCT1,104 participants3.1%Positive
In 1104 people with acne, a 12-week gel with benzoyl peroxide cleared pimples, blackheads, and whiteheads more than related combination gels and a placebo.
Triple-Combination Clindamycin Phosphate 1.2%/Adapalene 0.15%/Benzoyl Peroxide 3.1% Gel for Acne in Adult and Pediatric Participants.
Journal of drugs in dermatology : JDD2024RCT3.1%Positive
In a 12-week study of children and adults with acne, a gel with benzoyl peroxide used with 2 other ingredients cleared acne better than a placebo.
A randomized controlled double-blinded split-face prospective clinical trial to assess the efficacy, safety, and tolerability of a novel 3-step routine compared to benzoyl peroxide for the treatment of mild to moderate acne vulgaris.
Archives of dermatological research2024RCT21 participantsPositive
In a 12-week split-face trial of 21 adults with acne, benzoyl peroxide cleared pimples about as well as the other routine, but caused more irritation and dropouts.
Triple-Combination Clindamycin Phosphate 1.2%/Adapalene 0.15%/Benzoyl Peroxide 3.1% Gel for Moderate-to-Severe Acne in Children and Adolescents.
Journal of drugs in dermatology : JDD2024RCT173 participants3.1%Positive
In a 12-week clinical trial of 173 teens with moderate-to-severe acne, benzoyl peroxide used with clindamycin and adapalene cleared acne better than a placebo.
Clindamycin Phosphate 1.2%/Adapalene 0.15%/Benzoyl Peroxide 3.1% Gel in Participants With Moderate-to-Severe Acne: The Patient Journey.
Journal of drugs in dermatology : JDD2024RCT6 participants3.1%Positive
In 6 people with moderate-to-severe acne, a gel with benzoyl peroxide used with 2 other ingredients improved acne over 12 weeks.
Clindamycin Phosphate 1.2%/Adapalene 0.15%/Benzoyl Peroxide 3.1% Gel for Male and Female Acne: Phase 3 Analysis.
Journal of drugs in dermatology : JDD2024RCT3.1%Positive
In 12 weeks, a gel with benzoyl peroxide used with 2 other acne ingredients cleared acne better than a placebo in people with moderate-to-severe acne.
CABTREOTM (Clindamycin Phosphate, Adapalene, and Benzoyl Peroxide) Topical Gel.
Skinmed2024RCT363 participants3.1%Positive
In 363 people with moderate to severe acne, a gel with benzoyl peroxide used with 2 other ingredients cleared acne better than a placebo over 12 weeks.
Investigation of the effect of adapalene 0.3%/benzoyl peroxide 2.5% gel in Korean patients with acne: a randomized, double-blind clinical trial, with a histopathological and immunohistochemical study.
Italian journal of dermatology and venereology2024RCT49 participants2.5%Positive
In a 24-week trial of 49 Korean people with acne, benzoyl peroxide in a gel with adapalene cleared acne better than a placebo.
Evaluation of the efficacy of maintenance therapy for acne vulgaris using adapalene 0.1%/benzoyl peroxide 2.5% gel and benzoyl peroxide 2.5% gel for 24 weeks and assessment of atrophic acne scars using three-dimensional image analysis.
The Journal of dermatology2023RCT126 participants2.5%Positive
In a 24-week trial of 126 people with acne, benzoyl peroxide helped keep acne under control better than no treatment.
Efficacy and Safety of Clascoterone Cream 1% and Clindamycin 1.2%/Benzoyl Peroxide 5% Gel Treatment in Patients With Acne.
Journal of drugs in dermatology : JDD2026Clinical trial9 participants5%Positive
In a 16-week study of 9 people with moderate acne, benzoyl peroxide used with clindamycin and clascoterone was linked to clearer skin and fewer pimples.
Clindamycin Phosphate 1.2%/Adapalene 0.15%/ Benzoyl Peroxide 3.1% for Acne: Results From A 6-Month Open-Label Study.
Journal of drugs in dermatology : JDD2025Clinical trial25 participants3.1%Positive
In a 24-week study of 25 people with moderate acne, a gel with benzoyl peroxide used with clindamycin and adapalene improved acne and skin marks.
A 2.6% Benzoyl Peroxide AV Cleanser Specifically Designed for Sensitive Skin Offers Good Efficacy and Tolerability.
Journal of drugs in dermatology : JDD2024Clinical trial28 participants2.6%Mixed
In a 4-week study of 28 people with acne, a 2.6% benzoyl peroxide cleanser reduced pimples early, but the improvement at week 4 was not statistically significant.
Research context, not treatment advice. Studies are about the ingredient, not any one product.
Products we have confirmed contain Benzoyl Peroxide, from their ingredient lists.
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