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Peer-reviewed research on Tranexamic Acid, summarised in plain language. Every study links to its record on PubMed so you can read it yourself.
Efficacy and safety of microneedling with tranexamic acid versus microneedling with vitamin C in the treatment of melasma: a systematic review and meta-analysis.
Journal of medicine and life2026Meta-analysis232 participantsPositive
In a large review of 232 people with melasma, tranexamic acid put on the skin with microneedling faded dark patches about as well as vitamin C over 6 to 16 weeks.
Combining Microneedling and Tranexamic Acid for Melasma: A Systematic Review and Meta-Analysis.
Aesthetic plastic surgery2025Meta-analysisMixed
In a large review of trials in people with melasma, tranexamic acid used with microneedling was not better overall than other treatments, but it worked better than microneedling alone.
Comparative efficacy and safety of tranexamic acid for melasma by different administration methods: A systematic review and network meta-analysis.
Journal of cosmetic dermatology2024Meta-analysisPositive
In a large review of clinical trials in people with melasma, tranexamic acid put on the skin helped fade dark patches more than a placebo by week 8.
Efficacy and safety of mesotherapy with tranexamic acid versus vitamin C in the treatment of melasma: A meta-analysis and systemic review.
Journal of cosmetic dermatology2024Meta-analysis127 participantsPositive
In a large review of 127 people with melasma, tranexamic acid put into the skin improved dark patches and worked about as well as vitamin C.
The efficacy and safety of microneedling with topical tranexamic acid for melasma treatment: A systematic review and meta-analysis.
Journal of cosmetic dermatology2024Meta-analysisMixed
In a large review of clinical trials in people with melasma, tranexamic acid put on the skin with microneedling helped dark patches at 4 weeks, but later results were unclear.
Tranexamic acid as a therapeutic option for melasma management: meta-analysis and systematic review of randomized controlled trials.
The Journal of dermatological treatment2024Meta-analysis1,280 participantsPositive
In a large review of 1280 people with melasma, tranexamic acid put on the skin helped fade dark patches.
Effectiveness of laser and topical tranexamic acid combination therapy in melasma: An updated systematic review and meta-analysis of randomized controlled trials.
Lasers in medical science2023Meta-analysisPositive
In a large review of 9 clinical trials in people with melasma, tranexamic acid put on the skin with laser treatment faded dark patches more.
The Use of Tranexamic Acid and Microneedling in the Treatment of Melasma: A Systematic Review.
Cutis2024Systematic reviewPositive
A large review of clinical trials found that tranexamic acid put on the skin helped fade melasma, and worked about as well as hydroquinone.
Amber LED photobiomodulation versus tranexamic acid for the treatment of melasma: randomized controlled double-blind pilot trial.
Lasers in medical science2025RCT21 participants5%Neutral
In a 12-week trial of 21 women with melasma, tranexamic acid cream did not clearly fade dark patches.
Efficacy and safety of injectable sodium hyaluronate with vitamin C, tranexamic acid, and glutathione for pigmented dark circles.
The Journal of dermatological treatment2025RCT120 participantsPositive
In a 12-week clinical trial of 120 people with dark under-eye patches, a skin injection that included tranexamic acid helped fade the patches more than the control treatment.
Comparative study of different treatment modalities for melasma: introducing a novel nanotechnology-based tranexamic acid microemulsion.
Archives of dermatological research2025RCT52 participants1% and 3%Positive
In a 5-month trial of 52 women with melasma, tranexamic acid put on the skin reduced how dark and widespread the patches were.
Randomized Clinical Trial on the Efficacy of Oral Tranexamic Acid Versus Topical Tranexamic Acid in Treatment of Melasma.
Journal of cosmetic dermatology2025RCT50 participants5%Positive
In a 12-week trial of 50 women with melasma, tranexamic acid cream faded dark patches, and it worked about as well as oral tranexamic acid.
Evaluation of the Efficacy of a Serum Containing Niacinamide, Tranexamic Acid, Vitamin C, and Hydroxy Acid Compared to 4% Hydroquinone in the Management of Melasma.
Journal of cosmetic dermatology2025RCT60 participants1%Positive
In a 5-month trial of 60 women with melasma, a serum with tranexamic acid faded dark patches about as well as hydroquinone.
Microneedling-assisted delivery of metformin versus tranexamic acid in treating melasma: a randomized controlled study.
European journal of medical research2025RCT45 participantsPositive
In an 8-week trial of 45 women with melasma, tranexamic acid put on the skin with microneedling faded dark patches more than metformin or Kligman's formula.
Clinical study on the effectiveness of laser combined with topical tranexamic acid in the treatment of melasma.
Lasers in medical science2025RCT160 participantsPositive
In a clinical trial of 160 people with melasma, adding topical tranexamic acid to laser treatment faded dark patches more than laser alone.
Safety and efficacy of niosomal and conventional tranexamic acid/niacinamide vs. hydroquinone creams in melasma: A randomized, double-blind, case-controlled clinical trial.
Scientific reports2025RCT99 participants2% and 5%Positive
In a 3-month trial of 99 people with melasma, creams with tranexamic acid helped fade dark patches about as well as hydroquinone.
Treatment of Melasma with Tranexamic Acid Essence Combined with Iontophoresis: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.
Drug design, development and therapy2024RCT30 participantsPositive
In a 3-month clinical trial of 30 people with melasma, tranexamic acid put on the skin with iontophoresis faded dark patches more than a placebo.
The effectiveness and safety of 3% tranexamic acid cream vs. 4% hydroquinone cream for mixed-type melasma in skin of color: a double-blind, split-face, randomized controlled trial.
Acta dermatovenerologica Alpina, Pannonica, et Adriatica2024RCT20 participants3%Positive
In an 8-week trial of 20 people with melasma, tranexamic acid cream faded dark patches about as well as hydroquinone.
Safety and efficacy of a picosecond 755-nm alexandrite laser combined with topical tranexamic acid in the treatment of melasma.
Journal of cosmetic dermatology2024RCT35 participantsPositive
In a clinical trial of 35 people with melasma, tranexamic acid put on the skin with laser faded dark patches more than laser alone.
Efficacy, Safety, Satisfaction, Adherence to Treatment With Nano-Formulated Cysteamine Tranexamic Acid Cream to Treat Melasma.
Journal of drugs in dermatology : JDD2024RCT50 participantsPositive
In a 3-month clinical trial of 50 people with melasma, a cream with tranexamic acid helped fade dark patches.
Efficacy, safety, tolerability and treatment durability of microneedling plus topical tranexamic acid in combination with topical modified Kligman lightening formula for melasma: A four-arm assessor and analyst blinded randomized controlled clinical trial.
Journal of cosmetic dermatology2024RCT50 participants4% or 10%Mixed
In a 6-month trial of 50 people with melasma, tranexamic acid put on the skin helped more when used with a lightening cream, but worked poorly on its own.
Efficacy and safety of Politranexamide® liposomal emulsion on facial melasma: A comparative study.
Journal of cosmetic dermatology2023RCT26 participantsPositive
In a 12-week trial of 26 people with melasma, topical tranexamic acid faded dark patches more than the comparison product.
Effectiveness of combination therapy of broadband light and intradermal injection of tranexamic acid in the treatment of chloasma.
Journal of cosmetic dermatology2023RCT120 participantsMixed
In a 3-month trial of 120 women with melasma, tranexamic acid shots alone improved dark patches, but not more than oral tranexamic acid or light treatment alone.
Efficacy and Tolerability of a Topical Pigment-Correcting Serum in Melasma and Postinflammatory Hyperpigmentation.
Journal of drugs in dermatology : JDD2026Clinical trial30 participantsPositive
In a 16-week study of 30 women with melasma or dark marks after acne, a serum with tranexamic acid helped fade dark patches.
Research context, not treatment advice. Studies are about the ingredient, not any one product.
How we grade research for hyperpigmentationProducts we have confirmed contain Tranexamic Acid, from their ingredient lists.
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