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TXA Niacinamide 15 Serum

HyperpigmentationSerum

TXA Niacinamide 15 Serum — Reddit Reviews

by Medicube

85nextscore7 verdicts

Updated October 10, 2026

Tranexamic acid and niacinamide serum for dark spots; sticky and sometimes underwhelming.

What the community says

Backed by 77 studies

A tranexamic acid and niacinamide serum people reach for when hyperpigmentation is the main gripe. Reddit threads call out dark-spot help, but the texture gets called sticky and some users saw barely anything.

From Reddit

Backed by 16 threads from r/tretinoin, r/koreanskincare and 4 more.

Read the threads ↓

What people love

  • Dark-spot focus, not just a generic brightening serum
  • 5% tranexamic acid plus 15% niacinamide
  • Layers into AM routines without much fuss

Watch out for

  • Sticky finish shows up in user reports
  • A lot of people saw only mild or no change
  • Can feel like overkill if your routine is already actives-heavy

Product details

Where to buy

What the science says vs. what Reddit says

  • Hyperpigmentation

    Strong evidence

    Tranexamic Acid: 16 studies tested it on its own. See all 21 studies

    On Reddit: Acne-related spots get the clearest praise: one user says it definitely works, though they find it sticky. 6 mentions

    Both ingredients for hyperpigmentation

    Tranexamic Acid Strong evidence

    Studied at 1–5%this product: 5%

    Niacinamide Some evidence

    5 studies tested it on its own. See all 20 studies

    • All 5 studies that tested it on its own found it helped fade dark spots
    • On its own, it reduced facial darkening and made skin look lighter than a placebo
    • It also improved dark spots linked with sun damage in one clinical trial
  • Acne

    Some evidence

    Niacinamide: 6 studies tested it on its own. See all 17 studies

    What the studies found
    • Most studies found niacinamide helped acne
    • It often cleared acne about as well as clindamycin when put on the skin
    • Some studies found it helped reduce red, sore spots and pimples
    • Some evidence is still uncertain because some studies found no clear difference
  • Anti-Aging

    Some evidence

    Niacinamide: 3 studies tested it on its own. See all 9 studies

  • Skin Barrier

    Not proven yet

    Few or mixed studies. This claim isn't established.

    Niacinamide: 1 study tested it on its own. See all 17 studies

    What the studies found
    • The one study that tested it on its own found it helped the skin barrier
    • It lowered water loss through the skin
    • It increased the thickness of the outer skin layer

Research context, not treatment advice. Studies are about the ingredient, not necessarily this exact product.

Real Reddit threads — 20 mentions across 16 threads

Medicube TXA Niacinamide 15 Serum on Reddit, in one place — 16 threads from r/tretinoin, r/koreanskincare and 4 more, summarized.

“Apply Medicube TXA 15% Serum”

Positive

“I was very careful as I was also introducing Tranexamic Acid serum during the daytime to boost the hyperpigmentation fighting effects of the tret.”

Positive

“It has worked well for me though.”

Positive

“5. Medicube TXA 15%”

Positive

“The medicube TX serum is really good when paired with the toowongfoo for hyperpigmentation.”

Positive

“The medicube & twowongfoo are for the hyperpigmentation”

Positive

“I use the Medicube one, and it definitely works for acne hyperpigmentation spots. It is sticky.”

Mentioned

“the anua and medicube serums are similar, except medicube has 5% txa where anua has 4%. but they both have 10% niacinamide.”

Mentioned

“Medicube: also just OK. Didn’t notice much of a difference when I used it”

Mentioned

“I read sonewhere that medicube txa (with red/ pink dye) is carcinogenic due to the color substance used.”

Mentioned

“Not sure if it applies to anua”

Mentioned

“medicube txa (with red/ pink dye)”

Mentioned

“I usually follow with medicube txa niacinamide and moisturizer.”

Positive

“Instead of the txa niacinamide, i used good molecules HA serum and mositurizer.”

Positive

“Did this for 2 months and it actually made the clogging worse.”

Positive

“I have some hyperpigmentation and started using medicubes TXA serum in the mornings.”

Mentioned

“Too soon to tell if it’s improving things but I’m hopeful.”

Mentioned

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