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TXA Niacinamide 15 Serum

HyperpigmentationSerum

TXA Niacinamide 15 Serum — Reddit Reviews

by Medicube

85nextscore7 verdicts

Updated October 29, 2026

5% tranexamic acid plus niacinamide targets dark spots; sticky, mixed payoff.

What the community says

Backed by 70 studies

This is a brightening serum built around 5% tranexamic acid and niacinamide, and Redditors mainly reach for it on stubborn hyperpigmentation. Redditors range from “works wonders” to no visible difference; the sticky finish and reported clogging make YMMV real.

From Reddit

Backed by 17 threads from r/tretinoin, r/koreanskincare and 4 more.

Read the threads ↓

What people love

  • 5% tranexamic acid for dark-spot routines
  • Redditors report dramatic dark-spot improvement
  • Used in morning routines alongside tretinoin

Product details

What the science says vs. what Reddit says

  • Hyperpigmentation

    Some evidence

    Tranexamic Acid: 9 studies tested it directly. See all 19 studies

    On Reddit: Acne-related spots get the clearest praise: one user says it definitely works, though they find it sticky. 6 mentions

    Both ingredients for hyperpigmentation

    Tranexamic Acid Some evidence

    • Most studies found tranexamic acid helped fade melasma and other dark patches
    • Used on its own, it reduced how dark and widespread melasma patches were
    • Used with laser treatment, it often faded melasma more than laser alone
    • Different ways of using tranexamic acid often worked similarly, though some reviews found oral use or microneedling worked better
    • The most common side effects were stomach upset, skin irritation, and menstrual changes

    Studied at 2–5%this product: 5%

    Niacinamide Some evidence

    4 studies tested it directly. See all 17 studies

    • All 4 studies that tested it directly found it helped fade dark spots or patches
    • It reduced facial dark spots better than a moisturizer without niacinamide
    • Women with chloasma saw darker patches improve more when nicotinamide was added to salicylic acid
    • Studies also found facial skin looked lighter as dark spots faded
  • Acne

    Some evidence

    Niacinamide: 6 studies tested it directly. See all 17 studies

    What the studies found
    • Most studies found niacinamide helped acne
    • It often worked about as well as clindamycin when put on the skin
    • Some studies found it reduced red, sore spots and other pimples
    • Some research found the results were uncertain or showed no clear difference
  • Anti-Aging

    Some evidence

    Niacinamide: 2 studies tested it directly. See all 8 studies

    What the studies found
    • Both studies that tested it directly found it helped with signs of aging
    • It improved how firm and elastic the skin looked
    • It reduced wrinkles, uneven tone, redness, and yellowing
    • It helped skin hold more water and lowered water loss through the skin
  • Skin Barrier

    Not proven yet

    Few or mixed studies. This claim isn't established.

    Niacinamide: 1 study tested it directly. See all 17 studies

    What the studies found
    • The one study that tested it directly found it helped the skin barrier
    • It lowered water loss through the skin
    • It increased the thickness of the outer layer of skin

Research context, not treatment advice. Studies are about the ingredient, not necessarily this exact product.

Real Reddit threads — 21 mentions across 17 threads

Medicube TXA Niacinamide 15 Serum on Reddit, in one place — 17 threads from r/tretinoin, r/koreanskincare and 4 more, summarized.

“Apply Medicube TXA 15% Serum”

Positive

“I was very careful as I was also introducing Tranexamic Acid serum during the daytime to boost the hyperpigmentation fighting effects of the tret.”

Positive

“It has worked well for me though.”

Positive

“5. Medicube TXA 15%”

Positive

“The medicube TX serum is really good when paired with the toowongfoo for hyperpigmentation.”

Positive

“The medicube & twowongfoo are for the hyperpigmentation”

Positive

“I use the Medicube one, and it definitely works for acne hyperpigmentation spots. It is sticky.”

Mentioned

“the anua and medicube serums are similar, except medicube has 5% txa where anua has 4%. but they both have 10% niacinamide.”

Mentioned

“Medicube: also just OK. Didn’t notice much of a difference when I used it”

Mentioned

“I read sonewhere that medicube txa (with red/ pink dye) is carcinogenic due to the color substance used.”

Mentioned

“Not sure if it applies to anua”

Mentioned

“medicube txa (with red/ pink dye)”

Mentioned

“I usually follow with medicube txa niacinamide and moisturizer.”

Positive

“Instead of the txa niacinamide, i used good molecules HA serum and mositurizer.”

Positive

“Did this for 2 months and it actually made the clogging worse.”

Positive

“I have some hyperpigmentation and started using medicubes TXA serum in the mornings.”

Mentioned

“Too soon to tell if it’s improving things but I’m hopeful.”

Mentioned

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