nextbest

See what everyone's saying

Azelaic Acid Derivative Complex 10%

Combination SkinSerum

Azelaic Acid Derivative Complex 10% — Reddit Reviews

by Naturium

77nextscore14 verdicts

Updated October 30, 2026

Potassium azeloyl diglycinate fades brown marks and calms redness; irritation remains common.

What the community says

Backed by 53 studies

A lightweight serum built around potassium azeloyl diglycinate, with niacinamide and ethyl ascorbic acid, that Redditors use for redness, cheek texture, and lingering marks. It layers cleanly under makeup, yet reactive or rosacea-prone skin may sting or flush.

From Reddit

Backed by 17 threads from r/scacjdiscussion, r/AsianBeauty and 5 more.

Read the threads ↓

What people love

  • Redness visibly improves within days
  • Fades cheek hyperpigmentation; dries nicely
  • Lightweight, makeup-friendly, no pilling

Watch out for

  • Derivative, not actual azelaic acid
  • Can trigger facial redness and stinging
  • Niacinamide may aggravate rosacea-prone skin

Product details

Where to buy

Search on Amazon

What the science says

  • Acne

    Some evidence

    Niacinamide: 6 studies tested it directly. See all 17 studies

    What the studies found
    • Most studies found niacinamide helped acne
    • It often worked about as well as clindamycin when put on the skin
    • Some studies found it reduced red, sore spots and other pimples
    • Some research found the results were uncertain or showed no clear difference
  • Hyperpigmentation

    Some evidence

    Niacinamide: 4 studies tested it directly. See all 17 studies

    What the studies found
    • All 4 studies that tested it directly found it helped fade dark spots or patches
    • It reduced facial dark spots better than a moisturizer without niacinamide
    • Women with chloasma saw darker patches improve more when nicotinamide was added to salicylic acid
    • Studies also found facial skin looked lighter as dark spots faded
  • Anti-Aging

    Some evidence

    Niacinamide: 2 studies tested it directly. See all 8 studies

    What the studies found
    • Both studies that tested it directly found it helped with signs of aging
    • It improved how firm and elastic the skin looked
    • It reduced wrinkles, uneven tone, redness, and yellowing
    • It helped skin hold more water and lowered water loss through the skin
  • Skin Barrier

    Not proven yet

    Few or mixed studies. This claim isn't established.

    Niacinamide: 1 study tested it directly. See all 17 studies

    What the studies found
    • The one study that tested it directly found it helped the skin barrier
    • It lowered water loss through the skin
    • It increased the thickness of the outer layer of skin

Research context, not treatment advice. Studies are about the ingredient, not necessarily this exact product.

Real Reddit threads — 23 mentions across 17 threads

Naturium Azelaic Acid Derivative Complex 10% on Reddit, in one place — 17 threads from r/scacjdiscussion, r/AsianBeauty and 5 more, summarized.

“Naturium’s Azelaic Topical Acid 10% does not even contain actual Azelaic Acid (it’s a derivative).”

Cautionary

“And then there are companies that just lie.”

Cautionary

“So why should we just ‘trust the company?’”

Cautionary

“Kinda AB, the Naturium azelaic acid has done wonders for the KP on the face (cheeks).”

Positive

“the Naturium azelaic acid has done wonders for the KP on the face (cheeks).”

Positive

“Next I tried Naturium azelaic acid 10% and I saw a huge improvement within 2 days of use.”

Positive

“Azelaic Topical Acid 10% from Naturium brand.”

Positive

“This is the first thing that has worked for decreasing redness and pores.”

Positive

“I’ve been using Naturium azelaic acid and have seen improvement in my hyperpigmentation”

Positive

“I love the one from Naturium!”

Positive

“It feels hydrating and dries really nicely on my skin”

Positive

“I use the Naturium one and it works well with everything else, no pilling, no residue.”

Positive

“better than any other I’ve tried (Naturium, good molecules, peach slices).”

Positive

“Naturium, good molecules, peach slices”

Positive

“Have you recently started the Naturium Azelaic Acid? It contains niacinamide, which is an irritant to a lot of people, especially people with Rosacea.”

Cautionary

“AM - wash off ivermectin using baby shampoo or the tower 28 daily balancing gel cleanser, dry, natrium azelaic topical acid 10%, dry, then throughout the day tower 28 daily rescue facial spray.”

Cautionary

“This is how my face looked like when I finally figured out that Niacinamide was destroying my skin.”

Cautionary

Dupes & Alternatives

Compare all 12 alternatives

Reddit's best serums by concern, skin type or ingredient list

We use cookies to improve your experience. Learn more