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P-TIOX Anti-Wrinkle Serum

Anti-AgingSerum

P-TIOX Anti-Wrinkle Serum — Reddit Reviews

by SkinCeuticals

90nextscore6 verdicts

Updated October 18, 2026

Peptide serum for fine-line softening and glow; results vary sharply.

What the community says

Backed by 53 studies

A peptide serum for people chasing a Botox-adjacent look without immediately reaching for injections. Redditors report glow and softer fine lines, often after several weeks, though others used three bottles with no visible improvement.

From Reddit

Backed by 15 threads from r/30PlusSkinCare, r/tretinoin and 4 more.

Read the threads ↓

What people love

  • Peptide-focused fine-line serum
  • Glow is a recurring Reddit win
  • Some users say it helps Botox last longer

Watch out for

  • Slow payoff; one user needed two months
  • Three bottles did nothing for one user
  • Irritation reports led some users to stop it

Product details

Where to buy

Search on Amazon

What the science says vs. what Reddit says

  • Acne

    Some evidence

    Niacinamide: 6 studies tested it on its own. See all 17 studies

    What the studies found
    • Most studies found niacinamide helped acne
    • It often cleared acne about as well as clindamycin when put on the skin
    • Some studies found it helped reduce red, sore spots and pimples
    • Some evidence is still uncertain because some studies found no clear difference
  • Hyperpigmentation

    Some evidence

    Niacinamide: 4 studies tested it on its own. See all 17 studies

    What the studies found
    • All 4 studies that tested it on its own found it helped fade dark spots
    • It reduced facial dark spots better than a moisturizer without niacinamide
    • Some studies found skin looked lighter as dark spots faded
    • When used with salicylic acid, it improved dark patches more than salicylic acid alone
  • Anti-Aging

    Some evidence

    Niacinamide: 2 studies tested it on its own. See all 8 studies

    On Reddit: Lines Botox cannot tackle get attention here, with one user also praising the glow. 5 mentions

    What the studies found
    • Both studies that tested it on its own found it helped with signs of aging
    • It improved how firm and elastic the skin looked
    • It reduced wrinkles and uneven tone, including spots, redness, and yellowing
    • It helped the skin hold more water and reduced water loss through the skin
  • Skin Barrier

    Not proven yet

    Few or mixed studies. This claim isn't established.

    Niacinamide: 1 study tested it on its own. See all 17 studies

    What the studies found
    • The one study that tested it on its own found it helped the skin barrier
    • It lowered water loss through the skin
    • It increased the thickness of the outer skin layer

Research context, not treatment advice. Studies are about the ingredient, not necessarily this exact product.

Real Reddit threads — 31 mentions across 15 threads

SkinCeuticals P-TIOX Anti-Wrinkle Serum on Reddit, in one place — 15 threads from r/30PlusSkinCare, r/tretinoin and 4 more, summarized.

r/30PlusSkinCareBotox no longer works
48

“I’ve used SkinCeuticals P-tiox after getting Botox and I find it helps with lasting longer!”

Positive

“I also checked and it seems to have the same ingredients that others mentioned (argireline, peptides).”

Positive

“after getting Botox”

Positive

“I am scared about putting tret too close to my eyes, but I find that Skinceuticals P-Tiox helps a tiny bit.”

Positive

“those lines are always the first to return when I need another round of injections.”

Positive

“I am scared about putting tret too close to my eyes”

Positive

“use VitC + P-tiox from SkinCeuticals. My holy grail.”

Positive

“Literally makes my skin glow and helps with fine lines that Botox cannot tackle.”

Positive

“And in that order are the first two products I use on my face in the morning after washing.”

Positive
r/tretinoinExfoliation?
13

“Skinceuticals P-Tiox”

Positive

“Vitamin C- Skinceuticals CE Ferulic”

Positive

“Avene Cicalfate cream”

Positive

“My routine consists of tret, prequel multi quench, Skinceuticals HA intensifier multi Glycan, Skinceuticals PTIOX...”

Positive

“despite my intense skincare routine, my under eyes just continue to look like cracked mud.”

Positive

“not all at once of course and not all things on the same day”

Positive
4

“i introduced this and skinceuticals ptiox this week, had some irritation”

Mentioned

“so laid off the ptiox, assumed it was that.”

Mentioned

“Now I'm wondering!”

Mentioned

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