TNS Advanced+ Serum — Reddit Reviews
by SkinMedica
Updated October 23, 2026
Peptide and conditioned-media serum with visible anti-aging results; financially unsustainable.
What the community says
A peptide and human fibroblast conditioned-media serum aimed at fine lines, laxity, and overall skin quality. It suits dry, mature routines willing to spend for visible payoff, though newer peptide serums reportedly perform comparably for much less.
What this means for you
Backed by 19 threads from r/30PlusSkinCare, r/scacjdiscussion and 5 more.
Read the threads ↓What people love
- Peptide and conditioned-media formula with research behind it
- Noticeable eye-area and texture improvements for some users
Watch out for
- Luxury pricing becomes financially unsustainable
- Patch test first; irritation and safety concerns come up
Product details
Concerns
Skin Type
Product Traits
Key Ingredients
Where to buy
Real Reddit threads — 40 mentions across 19 threads
SkinMedica TNS Advanced+ Serum on Reddit, in one place — 19 threads from r/30PlusSkinCare, r/scacjdiscussion and 5 more, summarized.
“Skinmedica TNS has strong research.”
Mentioned
“For topicals, I’d go for research- based peptides”
Mentioned
“These may soften the look of your marionette lines a bit”
Mentioned
“TNS Advanced 😭”
Positive
“TNS Advanced+ Serum”
Positive
“TNS”
Positive
“SkinMedica TNS Advanced+ Serum in combo with lasers, microneedling, and Sculptra”
Positive
“TNS Advanced+ Serum in combo with lasers, microneedling, and Sculptra”
Positive
“SkinMedica TNS Advanced+ Serum”
Positive
“Epidermal growth factors. I almost never hear anyone on the skincare subs talk about it, but it's made my skin look 10x better than tretinoin ever did.”
Positive
“within a couple weeks my skin was radiant.... like I hadn't seen since childhood.”
Positive
“THIS. The skinmedica TNS serum is soooooo good!”
Positive
“I use SkinMedica TNS Advanced+ Serum, HA5 Hydra Collagen, SPF 30 sunscreen daily, and topical eye patches.”
Mentioned
“For context, I take pretty good care of my skin and overall health.”
Mentioned
“I use SkinMedica TNS Advanced+ Serum...”
Mentioned
“And some peptides and growth factors do work!”
Positive
“I borrowed my mom's skinmedica TNS after a treatment and wow it did calm down my skin immediately.”
Positive
“That said, there are certain ingredients that can make a genuinely noticeable difference.”
Positive
