
TXA Niacinamide 15 Serum — Reddit Reviews
by Medicube
Updated October 21, 2026
5% tranexamic acid and 15% niacinamide target dark spots; results vary.
What the community says
This brightening serum pairs 5% tranexamic acid with high-strength niacinamide for dark spots. Redditors use it alongside tretinoin or other brightening products, reporting wins unevenly; the sticky finish and occasional clogging make layering a YMMV situation.
What this means for you
What people love
- 5% TXA plus 15% niacinamide for dark-spot routines
- Pairs naturally with tretinoin-focused brightening routines
Product details
Concerns
Product Traits
Key Ingredients
Where to buy
What the science says vs. what Reddit says
Hyperpigmentation
Some evidence
Tranexamic Acid: 9 studies tested it on its own. See all 19 studies
On Reddit: Acne-related spots get the clearest praise: one user says it definitely works, though they find it sticky. 6 mentions
Both ingredients for hyperpigmentation
Tranexamic Acid Some evidence
- Most studies found it helped fade dark patches, especially in melasma
- It often worked about as well as other common dark-spot treatments
- Using it with other treatments often faded patches more than the other treatment alone
- Some studies found injected tranexamic acid, microneedling, or oral use worked better than other ways of using it
- The most common side effects were stomach upset, skin irritation, and menstrual changes
Studied at 2–5%this product: 5%
Niacinamide Some evidence
4 studies tested it on its own. See all 17 studies
Acne
Some evidence
Niacinamide: 6 studies tested it on its own. See all 17 studies
Anti-Aging
Some evidence
Niacinamide: 2 studies tested it on its own. See all 8 studies
Skin Barrier
Not proven yet
Few or mixed studies. This claim isn't established.
Niacinamide: 1 study tested it on its own. See all 17 studies
Research context, not treatment advice. Studies are about the ingredient, not necessarily this exact product.
Real Reddit threads — 21 mentions across 17 threads
Medicube TXA Niacinamide 15 Serum on Reddit, in one place — 17 threads from r/tretinoin, r/koreanskincare and 4 more, summarized.
“Apply Medicube TXA 15% Serum”
Positive
“I was very careful as I was also introducing Tranexamic Acid serum during the daytime to boost the hyperpigmentation fighting effects of the tret.”
Positive
“It has worked well for me though.”
Positive
“5. Medicube TXA 15%”
Positive
“The medicube TX serum is really good when paired with the toowongfoo for hyperpigmentation.”
Positive
“The medicube & twowongfoo are for the hyperpigmentation”
Positive
“I use the Medicube one, and it definitely works for acne hyperpigmentation spots. It is sticky.”
Mentioned
“the anua and medicube serums are similar, except medicube has 5% txa where anua has 4%. but they both have 10% niacinamide.”
Mentioned
“Medicube: also just OK. Didn’t notice much of a difference when I used it”
Mentioned
“I read sonewhere that medicube txa (with red/ pink dye) is carcinogenic due to the color substance used.”
Mentioned
“Not sure if it applies to anua”
Mentioned
“medicube txa (with red/ pink dye)”
Mentioned
“I usually follow with medicube txa niacinamide and moisturizer.”
Positive
“Instead of the txa niacinamide, i used good molecules HA serum and mositurizer.”
Positive
“Did this for 2 months and it actually made the clogging worse.”
Positive
“I have some hyperpigmentation and started using medicubes TXA serum in the mornings.”
Mentioned
“Too soon to tell if it’s improving things but I’m hopeful.”
Mentioned





