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TXA Niacinamide 15 Serum

HyperpigmentationSerum

TXA Niacinamide 15 Serum — Reddit Reviews

by Medicube

85nextscore7 verdicts

Updated October 21, 2026

5% tranexamic acid and 15% niacinamide target dark spots; results vary.

What the community says

Backed by 70 studies

This brightening serum pairs 5% tranexamic acid with high-strength niacinamide for dark spots. Redditors use it alongside tretinoin or other brightening products, reporting wins unevenly; the sticky finish and occasional clogging make layering a YMMV situation.

From Reddit

Backed by 17 threads from r/tretinoin, r/koreanskincare and 4 more.

Read the threads ↓

What people love

  • 5% TXA plus 15% niacinamide for dark-spot routines
  • Pairs naturally with tretinoin-focused brightening routines

Product details

Where to buy

What the science says vs. what Reddit says

  • Hyperpigmentation

    Some evidence

    Tranexamic Acid: 9 studies tested it on its own. See all 19 studies

    On Reddit: Acne-related spots get the clearest praise: one user says it definitely works, though they find it sticky. 6 mentions

    Both ingredients for hyperpigmentation

    Tranexamic Acid Some evidence

    • Most studies found it helped fade dark patches, especially in melasma
    • It often worked about as well as other common dark-spot treatments
    • Using it with other treatments often faded patches more than the other treatment alone
    • Some studies found injected tranexamic acid, microneedling, or oral use worked better than other ways of using it
    • The most common side effects were stomach upset, skin irritation, and menstrual changes

    Studied at 2–5%this product: 5%

    Niacinamide Some evidence

    4 studies tested it on its own. See all 17 studies

    • All 4 studies that tested it on its own found it helped fade dark spots
    • It reduced facial dark spots better than a moisturizer without niacinamide
    • Some studies found skin looked lighter as dark spots faded
    • When used with salicylic acid, it improved dark patches more than salicylic acid alone
  • Acne

    Some evidence

    Niacinamide: 6 studies tested it on its own. See all 17 studies

    What the studies found
    • Most studies found niacinamide helped acne
    • It often cleared acne about as well as clindamycin when put on the skin
    • Some studies found it helped reduce red, sore spots and pimples
    • Some evidence is still uncertain because some studies found no clear difference
  • Anti-Aging

    Some evidence

    Niacinamide: 2 studies tested it on its own. See all 8 studies

    What the studies found
    • Both studies that tested it on its own found it helped with signs of aging
    • It improved how firm and elastic the skin looked
    • It reduced wrinkles and uneven tone, including spots, redness, and yellowing
    • It helped the skin hold more water and reduced water loss through the skin
  • Skin Barrier

    Not proven yet

    Few or mixed studies. This claim isn't established.

    Niacinamide: 1 study tested it on its own. See all 17 studies

    What the studies found
    • The one study that tested it on its own found it helped the skin barrier
    • It lowered water loss through the skin
    • It increased the thickness of the outer skin layer

Research context, not treatment advice. Studies are about the ingredient, not necessarily this exact product.

Real Reddit threads — 21 mentions across 17 threads

Medicube TXA Niacinamide 15 Serum on Reddit, in one place — 17 threads from r/tretinoin, r/koreanskincare and 4 more, summarized.

“Apply Medicube TXA 15% Serum”

Positive

“I was very careful as I was also introducing Tranexamic Acid serum during the daytime to boost the hyperpigmentation fighting effects of the tret.”

Positive

“It has worked well for me though.”

Positive

“5. Medicube TXA 15%”

Positive

“The medicube TX serum is really good when paired with the toowongfoo for hyperpigmentation.”

Positive

“The medicube & twowongfoo are for the hyperpigmentation”

Positive

“I use the Medicube one, and it definitely works for acne hyperpigmentation spots. It is sticky.”

Mentioned

“the anua and medicube serums are similar, except medicube has 5% txa where anua has 4%. but they both have 10% niacinamide.”

Mentioned

“Medicube: also just OK. Didn’t notice much of a difference when I used it”

Mentioned

“I read sonewhere that medicube txa (with red/ pink dye) is carcinogenic due to the color substance used.”

Mentioned

“Not sure if it applies to anua”

Mentioned

“medicube txa (with red/ pink dye)”

Mentioned

“I usually follow with medicube txa niacinamide and moisturizer.”

Positive

“Instead of the txa niacinamide, i used good molecules HA serum and mositurizer.”

Positive

“Did this for 2 months and it actually made the clogging worse.”

Positive

“I have some hyperpigmentation and started using medicubes TXA serum in the mornings.”

Mentioned

“Too soon to tell if it’s improving things but I’m hopeful.”

Mentioned

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