No.5 Glutathione TXA Advanced Dark Spot Ampoule Concentrate — Reddit Reviews

• Hyperpigmentation

  Some evidence

  Tranexamic Acid: 9 studies tested it on its own. See all 19 studies→

  On Reddit: Acne-mark PIH gets specific mentions, with users saying it made a difference on lingering discoloration. 14 mentions

  Both ingredients for hyperpigmentation

  Tranexamic Acid · Some evidence

  • Most studies found it helped fade dark patches, especially in melasma
  • It often worked about as well as other common dark-spot treatments
  • Using it with other treatments often faded patches more than the other treatment alone
  • Some studies found injected tranexamic acid, microneedling, or oral use worked better than other ways of using it
  • The most common side effects were stomach upset, skin irritation, and menstrual changes

  Niacinamide · Some evidence

  4 studies tested it on its own. See all 17 studies→

  • All 4 studies that tested it on its own found it helped fade dark spots
  • It reduced facial dark spots better than a moisturizer without niacinamide
  • Some studies found skin looked lighter as dark spots faded
  • When used with salicylic acid, it improved dark patches more than salicylic acid alone

• Acne

  Some evidence

  Niacinamide: 6 studies tested it on its own. See all 17 studies→

  What the studies found

  • Most studies found niacinamide helped acne
  • It often cleared acne about as well as clindamycin when put on the skin
  • Some studies found it helped reduce red, sore spots and pimples
  • Some evidence is still uncertain because some studies found no clear difference

• Anti-Aging

  Some evidence

  Niacinamide: 2 studies tested it on its own. See all 8 studies→

  What the studies found

  • Both studies that tested it on its own found it helped with signs of aging
  • It improved how firm and elastic the skin looked
  • It reduced wrinkles and uneven tone, including spots, redness, and yellowing
  • It helped the skin hold more water and reduced water loss through the skin

• Skin Barrier

  Not proven yet

  Few or mixed studies. This claim isn't established.

  Niacinamide: 1 study tested it on its own. See all 17 studies→

  What the studies found

  • The one study that tested it on its own found it helped the skin barrier
  • It lowered water loss through the skin
  • It increased the thickness of the outer skin layer

Research context, not treatment advice. Studies are about the ingredient, not necessarily this exact product.